Volume 92 Issue 42 | p. 30 | Concentrates
Issue Date: October 20, 2014

Proton Source Guides Two-Way Selectivity

Asymmetric protonation features unusual enantioselectivity switch that occurs just from changing the proton source
Department: Science & Technology
News Channels: Organic SCENE
Keywords: stereocontrol, enantioselectivity, protonation, isoflavanones

Chemists have found an unusual switch in enantioselectivity––from 92% of one enantiomer to 91% of the other––by changing the proton source in a reaction used to synthesize isoflavanones (Chem. Eur. J. 2014, DOI: 10.1002/chem.201405246). According to the researchers, this is the first example of dual stereocontrol in an asymmetric protonation reaction. The observation could ease the synthesis of customized isoflavanones, which are plant metabolites . . .

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