Volume 92 Issue 6 | p. 27 | Concentrates
Issue Date: February 10, 2014

Faster And Cleaner Peptide Synthesis

High-efficiency microwave method cuts cycle times to four minutes while achieving high-purity peptides and reducing chemical waste
Department: Science & Technology | Collection: Green Chemistry, Life Sciences
News Channels: Organic SCENE
Keywords: microwave, peptide synthesis, organic synthesis, process chemistry

Solid-phase peptide synthesis is an indispensable method for constructing natural and modified peptide sequences. But the multistep process needed is time-consuming and generates a significant amount of chemical waste relative to the small amount of peptide generated. For example, a 100-mg synthesis of a peptide 20 amino acids long can take 24 hours to complete and produce several liters of waste. Jonathan M. Collins and coworkers at CEM Corp., a manufacturer of . . .

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