Issue Date: May 11, 2015
NMR Method Detects Glycosylations On Intact Proteins
Glycosylation is the most abundant type of protein posttranslational modification. However, there’s no direct method for characterizing the chemical changes. Mass spectrometry methods, which require enzymatic digestion of the protein, can reveal the location and composition of a glycosylation, but they can’t determine the exact stereochemistry or glycosidic linkage. Mario Schubert, Michal J. Walczak, and coworkers at ETH Zurich have reported a simple and direct nuclear magnetic resonance spectroscopy method for detecting . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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