Volume 93 Issue 25 | p. 6 | News of The Week
Issue Date: June 22, 2015 | Web Date: June 19, 2015

Novel Antimalarial Agent Has New Mode Of Action

Drug Discovery: Quinoline diamine blocks protein translation in malaria parasite, interfering with multiple stages of the organism’s life cycle
By Judith Lavelle
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: malaria, antimalarials, neglected diseases, drug discovery

A new chemical agent effective against a malaria parasite at multiple life stages has joined the ranks of potential new treatments. Researchers at the University of Dundee, in Scotland, have discovered a quinoline diamine that blocks protein translation in Plasmodium falciparum, a malaria parasite, and eventually kills the organism (Nature 2015, DOI: 10.1038/nature14451).

Antimalarial drugs typically interfere with only . . .

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