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Business

Celgene, Nurix Target Ubiquitin Proteasome

by Michael McCoy
September 21, 2015 | A version of this story appeared in Volume 93, Issue 37
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The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis. Potential applications are in oncology, inflammation, and immunology. Celgene will pay Nurix $150 million up front and up to $405 million in milestone and other payments. Nurix CEO Arthur T. Sands calls Celgene the “preeminent” company working in UPS-targeting therapies.

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