Volume 93 Issue 42 | p. 7 | News of The Week
Issue Date: October 26, 2015 | Web Date: October 20, 2015

Understanding Of Bacterial Protein’s Defense Strategy Could Lead To Antibiotics

Mechanistic Studies: Two research teams unveil how the transcription factor CueR helps regulate copper levels in bacteria
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: antibiotics, bacteria, bacterial defenses, efflux pumps

Bacteria have evolved molecular strategies for regulating the export of toxic metals from their innards. Two independent studies now pinpoint the details of one of these strategies, which protects bacteria from toxic copper concentrations. The work could aid the discovery of antibiotics that target this process to compromise bacterial defenses.

The studies provide complementary structural and mechanistic views that reveal how a transcription factor called CueR activates or represses the gene copA, which encodes the . . .

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