Issue Date: November 16, 2015
Amides Succumb To Suzuki–Miyaura Coupling, Thanks To Nickel Catalyst
The first nickel-catalyzed Suzuki-Miyaura coupling using an amide derivative as a cross-coupling partner has been reported by chemists at UCLA (Nat. Chem. 2015, DOI: 10.1038/nchem.2388). Suzuki-Miyaura couplings are wildly popular for forging C–C bonds: The prototype reaction uses a palladium catalyst to link an organoboron reagent with an electrophile, such as an organohalide. In recent years, chemists have investigated nickel catalysts for these types of reactions because the metal . . .
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