Volume 93 Issue 45 | p. 30 | Concentrates
Issue Date: November 16, 2015

Watching CRISPR/Cas9 At Work Unveils Its Search Strategy

Biochemistry: The famous gene-editing machinery can dig deep into locked-down areas of the genome
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: CRISPR, Cas9, genome editing

The buzz about how easy it is to use the CRISPR/Cas9 genome-editing machinery has inspired the tool’s widespread application. Researchers rave about the simplicity of using the system to cut and paste DNA into a variety of organisms with the aid of an RNA guide. But little is known about the kinetics and search strategy of the wunderkind genome editor, an information vacuum tackled recently by a team of scientists led by Jennifer A. Doudna . . .

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