Volume 93 Issue 7 | p. 27 | Concentrates
Issue Date: February 16, 2015

Peptide Mimic Blocks Painful Opioid Side Effect

Orally active compound prevents pain hypersensitivity produced during prolonged opioid use
Department: Science & Technology
News Channels: Organic SCENE, Biological SCENE
Keywords: opioids, pain relief, hyperalgesia, neuropeptide FF receptors

When patients take opioid drugs such as morphine to treat chronic pain, they often develop tolerance to the medication, needing higher and higher doses to get relief. Some researchers think this is caused, in part, by opioid-induced hyperalgesia (OIH)—a hypersensitivity to pain brought on by long-term use of the drugs. Now researchers report an orally active compound that blocks this effect in mice, possibly leading to a therapeutic that lessens opioid side effects (ACS Chem. . . .

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