Volume 94 Issue 13 | p. 6 | News of The Week
Issue Date: March 28, 2016 | Web Date: March 24, 2016

Chemists cut in half the number of steps needed to synthesize phorbol

Nineteen-step enantioselective synthesis opens up avenues to previously inaccessible analogs of this biologically active compound
Department: Science & Technology
News Channels: Organic SCENE
Keywords: total synthesis, phorbol, enatioselective, organic chemistry

For the first time, chemists have completed an enantioselective total synthesis of the complex natural product (+)-phorbol. And they did it with a route that requires only 19 steps. That’s a dramatic cut in chemical transformations from previous approaches, which took 40 to 52 steps to make a racemic mixture of the compound.

Since its discovery more than 80 years ago, densely functionalized, polycyclic phorbol has intrigued both chemists and biologists. One source of phorbol . . .

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