Volume 94 Issue 14 | p. 7 | News of The Week
Issue Date: April 4, 2016 | Web Date: April 1, 2016

High-resolution NMR structure of Parkinson’s disease fibril solved

Core of α-synuclein fibril has complex structure, including unusual Greek key topology
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: structural biology, neuroscience, Parkinson’s disease, amyloid fibrils, NMR spectroscopy

The hallmarks of many neurodegenerative diseases are brain proteins glomming together into amyloid fibrils. In Parkinson’s disease, for example, α-synuclein forms the fibril culprits.

So far, structural information on α-synuclein fibrils has been limited: Scientists have obtained high-resolution structures of parts of the fibrils, as well as low-resolution microscopy images of full-length ones.

Now, Chad M. Rienstra of the University of . . .

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