Volume 94 Issue 20 | p. 9 | News of The Week
Issue Date: May 16, 2016 | Web Date: May 11, 2016

Custom dirhodium catalysts zero in on select alkane bonds

Catalyst-controlled carbene-insertion chemistry improves enantioselective C–H functionalization
Department: Science & Technology
News Channels: Materials SCENE, Organic SCENE
Keywords: organic synthesis, C–H activation, C–H functionalization, selectivity, carbene, rhodium

A leading synthetic challenge for chemists is how to precisely target a single C–H bond for reaction among many similar-looking ones in an organic molecule. Carefully crafted transition-metal catalysts have led to some success in modifying molecules that contain a double bond or a functional group adjacent to the target C–H to guide the reaction. Some catalysts have even worked with alkanes that are only made up of C–H bonds. But complete control of C–H . . .

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