Understanding ‘chemo brain’ | Chemical & Engineering News
Volume 94 Issue 21 | p. 9 | Concentrates
Issue Date: May 23, 2016

Understanding ‘chemo brain’

Cancer drug carboplatin impairs neurotransmitter release in rats, a possible cause of cognitive decline after chemotherapy
Department: Science & Technology
News Channels: Biological SCENE
Keywords: neuroscience, cancer, chemotherapy, dopamine, serotonin, carboplatin

About 30% of cancer patients who receive chemotherapy later suffer from so-called chemo brain, a condition characterized by memory loss, attention deficits, and decreased problem-solving abilities. Scientists know little about how anticancer drugs lead to this cognitive decline. But a new study reports that treating rats with the drug carboplatin impairs the release of dopamine and serotonin, which are neurotransmitters that play key roles in many cognitive functions affected by chemo brain (ACS Chem. Neurosci. . . .

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