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GSK and Verily launch Galvani Bioelectronics

Drug giant and tech firm form a company to create therapies that use implantable devices

by Ann M. Thayer
August 4, 2016 | APPEARED IN VOLUME 94, ISSUE 32

Credit: GlaxoSmithKline
Galvani Bioelectronics envisions putting electronic devices around nerve bundles to treat diseases as depicted in this drawing.
Credit: GlaxoSmithKline
Galvani Bioelectronics envisions putting electronic devices around nerve bundles to treat diseases as depicted in this drawing.

GlaxoSmithKline has joined with Verily Life Sciences to set up Galvani Bioelectronics, which will focus on treating chronic illnesses by controlling electrical impulses in the body. GSK and Verily, the former Google Life Sciences business, will initially invest up to $718 million over seven years to support R&D at Galvani.

Having made a concerted push into the bioelectronics area in 2012, GSK will now put its in-house efforts into Galvani for a 55% stake. The start-up will be housed at GSK’s Stevenage, England, R&D site with research also conducted in South San Francisco. Kris Famm, GSK’s vice president of bioelectronics R&D, will become Galvani’s president.

Galvani will combine GSK’s capabilities with Verily’s technical expertise in miniaturizing low-power electronics and in developing implantable devices, data analytics, and software for clinical applications. Galvani will initially employ about 30 scientists, engineers, and clinicians.

GSK says it has already seen encouraging proof of principle results in animal models in a range of diseases. And it anticipates that the first bioelectronic therapies could be ready for approval within 10 years. To achieve this, Galvani will focus on showing clinical evidence in inflammatory, metabolic, and endocrine disorders, including diabetes.

Although neurostimulators are available to treat epilepsy, pain, and other conditions, GSK envisions much tinier devices attached directly to nerves. These devices will be designed with better clinical insight and more precise neural control, the company claims. Ultimately, the goal is to close the therapeutic loop by having devices that can measure conditions, analyze data, and adjust treatment as needed.

To advance its bioelectronics agenda, GSK spent $50 million in 2013 to set up Action Potential Venture Capital, which has invested in at least five companies. Last month, one of these, SetPoint Medical, reported clinical trial data demonstrating that stimulating the vagus nerve with an implantable bioelectronic device inhibits cytokine production and significantly reduces rheumatoid arthritis symptoms (Proc. Natl. Acad. Sci. USA 2016, DOI: 10.1073/pnas.1605635113).

GSK has also established a network of about 50 research collaborations. In late 2014, it launched a $5 million Innovation Challenge Fund to support academic and small company bioelectronics-related R&D teams. Three finalist teams remain and GSK hopes to award a $1 million prize by year-end.



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