Volume 94 Issue 35 | p. 11 | News of The Week
Issue Date: September 5, 2016 | Web Date: September 2, 2016

Organometallic reaction catalyzed in living cells

Artificial enzyme with organometallic active site catalyzes a nonnatural reaction, olefin metathesis, in bacteria
Department: Science & Technology
News Channels: Biological SCENE
Keywords: catalysis, artificial enzyme, olefin metathesis

Organometallic catalysts are useful in lab research, and some are used industrially. They generally don’t work well in living cells. But researchers have now assembled an artificial enzyme with an organometallic active site in bacteria and coaxed it to catalyze an industrially relevant reaction that has never occurred before in live cells. They also used directed evolution, a lab mimic of natural evolution, to optimize and customize the catalyst in vivo.

The work could lead . . .

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