Volume 94 Issue 38 | p. 11 | Concentrates
Issue Date: September 26, 2016

Blue-light special on perfluoroalkylations

Combining photochemical synthesis with a continuous-flow reactor leads to practical kilogram-scale arene trifluoromethylations
Department: Science & Technology
News Channels: Analytical SCENE, Organic SCENE, Environmental SCENE
Keywords: process chemistry, trifluoromethylation, fluorination, photochemistry, flow reactor

Direct trifluoromethylation of aromatic rings is an important synthetic tool for chemists. Although an abundance of new methods that use less harsh reagents, have improved product selectivity, and minimize waste have been reported during the past decade, cost-effective scalable processes have remained underdeveloped. Corey R. J. Stephenson and his coworkers at the University of Michigan in collaboration with process chemistry researchers at Eli Lilly & Co. may . . .

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