Volume 94 Issue 38 | pp. 10-11 | Concentrates
Issue Date: September 26, 2016

RNA G-quadruplexes are scarce in eukaryotic cells

Eukaryotic cell RNAs have a lot of G-quadruplexfoldable regions but less actual folding than expected
Department: Science & Technology
News Channels: Biological SCENE
Keywords: biochemistry, RNA G-quadruplex, RNA, guanine, quartet, potassium

Researchers would like to better understand four-stranded RNA structures called RNA G-quadruplexes (RG4s), which are reported to play key roles in neurodegenerative diseases and cancer. Certain RNA sequence regions fold readily into RG4s in potassium solution, and most scientists believed those regions also formed RG4s in cells, where potassium is plentiful. To evaluate that assumption, Junjie U. Guo and David P. Bartel of the Whitehead Institute for Biomedical Research and MIT developed a new technique . . .

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