Volume 94 Issue 42 | p. 10 | Concentrates
Issue Date: October 24, 2016

Attaching ‘unlinkable’ drugs to antibodies

Quaternary ammonium group connects drugs to antibodies for targeted delivery
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: drug delivery, linker, bioconjugate, peptide

Attaching a small-molecule drug to a targeting agent such as an antibody can improve the delivery of the drug. A common way to achieve that with antibodies is using a linker that connects to the drug through an amide or carbamate functional group. But tertiary and heteroaryl amines common to many drug molecules lack a place for such a connection, leading researchers to deem them “unlinkable.” A team led by Thomas H. Pillow of Genentech . . .

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