Volume 94 Issue 42 | p. 11 | Concentrates
Issue Date: October 24, 2016

Tapping into the human microbiome yields MRSA-active antibiotics

Researchers develop new bioinformatics-based approach to natural product discovery
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: antibiotics, microbiome, bioinformatics, MRSA, humimycin

Microbes are full of undiscovered molecules, including antibiotics. But many species remain difficult to culture or simply contain large swaths of genes that remain inactive under laboratory conditions. Hoping to harvest untapped molecules without growing a single cell, Sean F. Brady of Rockefeller University and colleagues looked to genomic data from the human microbiome for inspiration. “Genomic sequences are coming at us fast, and we need tools . . .

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