Volume 94 Issue 49 | p. 12 | Concentrates
Issue Date: December 19, 2016

Chiral Lewis acid catalyzes asymmetric photocycloaddition

Reaction takes place through triplet energy transfer instead of photoinduced electron transfer
Department: Science & Technology
News Channels: Organic SCENE
Keywords: photochemistry, triplet energy transfer

Being able to control the stereochemistry of organic reactions is important when making certain molecules, such as drug candidates or natural products. Although photochemistry allows chemists to create structural elements that are difficult to access in other ways, such as cyclobutanes, it can be tough to do photochemical reactions enantio­selectively. Chemists at the University of Wisconsin, Madison, led by Tehshik P. Yoon now report an asymmetric [2 + 2] photocycloaddition of 2′-hydroxychalcones (Science 2016, DOI: . . .

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