Issue Date: December 19, 2016
Chiral Lewis acid catalyzes asymmetric photocycloaddition
Being able to control the stereochemistry of organic reactions is important when making certain molecules, such as drug candidates or natural products. Although photochemistry allows chemists to create structural elements that are difficult to access in other ways, such as cyclobutanes, it can be tough to do photochemical reactions enantioselectively. Chemists at the University of Wisconsin, Madison, led by Tehshik P. Yoon now report an asymmetric [2 + 2] photocycloaddition of 2′-hydroxychalcones (Science 2016, DOI: . . .
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