• CORRECTION: This story was updated on Jan. 12, 2016, to correct the percent conversion for the oxime reaction after three freezing and thawing cycles.
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Web Date: January 8, 2016

Happy Accident Leads To Faster Synthesis

Protein Chemistry: Power outage reveals that oxime ligation speeds up below freezing
Department: Science & Technology
News Channels: Organic SCENE
Keywords: protein label, oxime, freezing, reaction rates

When a power outage hit the labs of biochemist Tilman M. Hackeng of the University of Maastricht, his colleague Stijn M. Agten rushed to remove some samples from their ultra-performance liquid chromatography-tandem mass spectrometry machine. Agten was monitoring the progress of an oxime ligation reaction, and to give himself time to reboot the machine, he froze his samples to -20 ˚C, expecting to slow the reaction rates and allow him to salvage something from his . . .

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