Issue Date: March 13, 2017 | Web Date: March 9, 2017
Enzyme-inspired route to heterocycle functionalization
Chemists often use C–H activation to help replace specific hydrogen atoms in organic compounds with complex functional groups. This strategy generally involves covalently bonding a reagent containing a C–H-activating group, such as a palladium atom, to a substrate that already has a directing functional group. The directing group steers the C–H activator to the desired C–H bond. Once the bond breaks, a new functional group replaces hydrogen and the directing group is removed.
A new . . .
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- Chemical & Engineering News
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