Volume 95 Issue 11 | p. 8 | News of The Week
Issue Date: March 13, 2017 | Web Date: March 9, 2017

Enzyme-inspired route to heterocycle functionalization

Bifunctional metal agents reversibly coordinate heterocycles and derivatize them at remote sites
Department: Science & Technology
News Channels: Materials SCENE, Organic SCENE
Keywords: C–H activation, catalysis, heterocycles

Chemists often use C–H activation to help replace specific hydrogen atoms in organic compounds with complex functional groups. This strategy generally involves covalently bonding a reagent containing a C–H-activating group, such as a palladium atom, to a substrate that already has a directing functional group. The directing group steers the C–H activator to the desired C–H bond. Once the bond breaks, a new functional group replaces hydrogen and the directing group is removed.

A new . . .

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