Volume 95 Issue 17 | News of The Week
Issue Date: April 24, 2017 | Web Date: April 19, 2017

New dyes enable super-multicolor imaging

Nitrile- and alkyne-containing dyes improve the sensitivity and specificity of Raman microscopy
Department: Science & Technology
Keywords: imaging, Raman, multiplexing, dyes, SRS, stimulated Raman scattering

A new method expands the number of molecules that can be imaged simultaneously in biological samples. Wei Min and coworkers at Columbia University demonstrate that their method could resolve 24 dye-labeled molecules at a time with the method—20 with a new version of stimulated Raman scattering (SRS) microscopy called electronic preresonance SRS and four with fluorescence microscopy (Nature 2017, DOI: 10.1038/nature22051).

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