New way to make chiral arenes | April 24, 2017 Issue - Vol. 95 Issue 17 | Chemical & Engineering News
Volume 95 Issue 17 | p. 5 | News of The Week
Issue Date: April 24, 2017 | Web Date: April 21, 2017

New way to make chiral arenes

Combined chemical and biocatalytic method installs group important in drug design
Department: Science & Technology
News Channels: JACS In C&EN, Organic SCENE
Keywords: synthesis, myoglobin, carbenes, drug discovery, trifluorocyclopropane

A trifluoromethyl-substituted cyclopropane group can play a key role in a drug candidate. The group’s rigid cyclopropyl ring can increase the compound’s lipophilicity and metabolic stability while its fluorines can boost the candidate’s stability and ability to permeate membranes. But installing trifluoromethylcyclopropyl groups in a highly enantioselective manner is hard.

A team led by Rudi Fasan at the University of Rochester now reports a combined chemical and biocatalytic approach that could make it easier to . . .

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