Volume 95 Issue 23 | p. 7 | News of The Week
Issue Date: June 5, 2017 | Web Date: June 1, 2017

Vancomycin triple threat developed

Modified drug uses three mechanisms of action to treat drug-resistant bacterial infections
Department: Science & Technology
Keywords: drug discovery, vancomycin, bacteria, antiobiotics

Researchers have created a modified form of the approved antibacterial drug vancomycin (Vancocin) that has three independent mechanisms of action, boosting its potency and minimizing the potential for bacteria to develop resistance to it.

Vancomycin, a bacterial natural product, had long been an antibiotic of last resort because it remained effective against drug-resistant bacteria after other medications stopped working. But bacteria have now evolved defenses against vancomycin, which works by inhibiting transpeptidase, an enzyme that . . .

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