Issue Date: July 3, 2017 | Web Date: June 29, 2017
Chemists discover biology’s version of the Friedel-Crafts alkylation
By chemistry standards, the Friedel-Crafts alkylation is a venerable reaction. First reported by chemists Charles Friedel and James Crafts in 1877, the reaction attaches an alkyl substituent to an aromatic ring using an alkyl halide as one of the reactants. It turns out that Nature has been doing this reaction for even longer—scientists just didn’t know it until now.
Harvard University’s Emily P. Balskus, Hitomi Nakamura, and Erica E. Schultz have discovered . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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