Volume 95 Issue 29 | p. 9 | Concentrates
Issue Date: July 17, 2017

Automating reaction discovery

Approach combines chemical design and informatics to find new chemical transformations
Department: Science & Technology
News Channels: Organic SCENE
Keywords: Synthesis, automation, macros

When hunting for novel chemical reactions, the more transformations chemists can do, the more likely they are to find something new. University of California, Berkeley, chemists John F. Hartwig and Konstantin Troshin have come up with an approach that lets reaction hunters run 75,000 possible reactions in just a matter of days using only a sealed 96-well plate, a gas chromatography/mass spectrometry instrument, and an analytical suite of Microsoft Excel macros . . .

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