Sweeter hookups between sugars using a macrocyclic catalyst | January 16, 2017 Issue - Vol. 95 Issue 3 | Chemical & Engineering News
Volume 95 Issue 3 | p. 5 | News of The Week
Issue Date: January 16, 2017

Sweeter hookups between sugars using a macrocyclic catalyst

Bis-thiourea compound helps stereospecifically build β-glycoside sugar linkages
Department: Science & Technology
Keywords: synthesis, glycoside, sugar, oligosaccharide, polysaccharide

Assembling oligosaccharides and polysaccharides can be tricky business. The steric and electronic elements that come into play when hooking one sugar onto another makes the synthesis of these molecules unpredictable. Now, inspired by the enzymes that connect sugars to one another in cells, Eric N. Jacobsen and coworkers at Harvard University have developed a macrocyclic catalyst that predictably and reliably builds certain types of sugar linkages—known as β-glycosidic bonds—in a stereospecific manner . . .

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