Two new ways to get proteins into cells | July 24, 2017 Issue - Vol. 95 Issue 30 | Chemical & Engineering News
Volume 95 Issue 30 | pp. 8-9 | Concentrates
Issue Date: July 24, 2017

Two new ways to get proteins into cells

Disrupting endosomes and skipping endosomes entirely ease cell entry
Department: Science & Technology
News Channels: Biological SCENE
Keywords: drug delivery, antibodies, proteins, nanobodies, cell-penetrating peptides

Proteins can be important therapeutics, but in many cases their potential is limited because their polarity and large size prevent them from traversing cell membranes and entering cells, where their molecular targets may be located. Cell-penetrating peptides can shepherd proteins into cells, but in many cases the proteins are taken up by and retained in cell endosomes and thus still don’t reach the cytosol, the aqueous component of the cytoplasm. Two groups have now devised . . .

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