Volume 95 Issue 36 | p. 9 | Concentrates
Issue Date: September 11, 2017

Cross metathesis cleaves and restitches single bonds

Method merges two four-membered rings into an eight-membered macrocycle
Department: Science & Technology
News Channels: Organic SCENE, JACS In C&EN
Keywords: Synthesis, cross metathesis, synthesis, palladium catalysis, silacyclobutane

Chemists have developed an array of chemical tools that rely on reactive carbon-carbon π bonds or on polar bonds in which charge is unevenly shared between the atoms to drive the formation of new carbon-carbon bonds. Yet methods that act on challenging, nonpolar carbon-carbon bonds are few. Researchers led by Masahiro Murakami of Kyoto University have expanded the synthetic options by demonstrating the efficient exchange of two low-polarity σ bonds in . . .

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