Volume 95 Issue 39 | p. 11 | Concentrates
Issue Date: October 2, 2017

Radical reaction caught on the rebound

With FeOH model system, chemists observe key step in hydroxylation of C–H bonds for the first time
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Reaction mechanisms, radical rebound, cytochrome P450

For more than 40 years, chemists and biologists have used the radical rebound mechanism to describe what happens when enzymes with transition metals, such as cytochrome P450, hydroxylate C–H bonds. Such enzymes first remove a hydrogen atom from a C–H bond using a high-valent metal-oxo species. This produces a carbon radical and a metal-OH intermediate that then rebounds—the hydroxyl group moves onto the carbon radical and the metal is reduced by one electron. Although plenty . . .

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