Volume 95 Issue 39 | p. 10 | Concentrates
Issue Date: October 2, 2017

Revised view of Huntington’s protein misfolding mechanism

Study of monomeric protein seems to invalidate ‘rusty hinge’ mechanism
Department: Science & Technology
Keywords: Protein folding, Huntington's disease, huntingtin, misfolding

Huntington’s disease, a lethal neurodegenerative condition, is believed to be caused by misfolding of mutated versions of huntingtin protein in which a glutamine-containing sequence is repeated too many times. But how the protein misfolds is still uncertain. Researchers have speculated that the conformation of monomeric huntingtin undergoes a sharp transition when the number of glutamine repeats exceeds 36 or 37, making the domain inflexible, like a rusty hinge. However, mutant huntingtin monomers have been difficult . . .

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