Volume 95 Issue 46 | p. 6 | News of The Week
Issue Date: November 20, 2017

Proteomics goes native

Method allows native mass spectrometry to evaluate multitudes of proteins in their intact, biological forms
Department: Science & Technology
Keywords: Proteomics, mass spectrometry, top-down

When scientists analyze proteins with mass spectrometry, they typically denature the biomolecules, causing the proteins’ biologically relevant forms and composition to disappear. In contrast, so-called native mass spectrometry allows proteins and their complexes to remain intact during analysis.

For the past 15 years, though, native mass spectrometry has been relegated to analyzing specific, targeted protein complexes rather than unknown mixtures of them, says Neil L. Kelleher, a professor of chemistry at . . .

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