Volume 95 Issue 6 | p. 7 | News of The Week
Issue Date: February 6, 2017 | Web Date: February 2, 2017

Breaking isopropyl’s symmetry with C–H activation

Palladium-ligand combo locks up isopropyl moiety to generate chiral molecules from feedstock derivative
Department: Science & Technology
News Channels: Organic SCENE
Keywords: C–H activation, isobutyric acid, desymmetrization

When it comes to classic human beauty, people seem to prefer symmetry in facial features and figures. But chemists synthesizing drug candidates doggedly pursue asymmetry in their molecules. That’s because asymmetric molecules, or chiral compounds, have distinct properties arising from their stereochemistry. Being able to make such stereogenic centers directly saves chemists time and resources.

Chemists at Scripps Research Institute California and Bristol-Myers Squibb now report a way to break the symmetry of an isopropyl . . .

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