Issue Date: February 6, 2017 | Web Date: February 3, 2017
New mechanism for a methylating enzyme
A team of researchers in China has found a reaction mechanism unprecedented for the many enzymes that add methyl groups to biomolecules.
Most of these so-called methyltransferases depend on S-adenosylmethionine (SAM) as a methyl donor, plucking off the molecule’s methyl group and relocating it either through an SN2 mechanism or through a radical mechanism. Many scientists thought this type of SAM-dependent enzyme exclusively produced S-adenosylhomocysteine as a coproduct during the transfer.
A team led by . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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