New mechanism for a methylating enzyme | February 6, 2017 Issue - Vol. 95 Issue 6 | Chemical & Engineering News
Volume 95 Issue 6 | p. 7 | News of The Week
Issue Date: February 6, 2017 | Web Date: February 3, 2017

New mechanism for a methylating enzyme

Radical SAM enzyme uses unexpected molecule as a methyl donor
Department: Science & Technology
Keywords: biocatalysis, radical SAM enzyme, mechanism, methyltransferase

A team of researchers in China has found a reaction mechanism unprecedented for the many enzymes that add methyl groups to biomolecules.

Most of these so-called methyltransferases depend on S-adenosylmethionine (SAM) as a methyl donor, plucking off the molecule’s methyl group and relocating it either through an SN2 mechanism or through a radical mechanism. Many scientists thought this type of SAM-dependent enzyme exclusively produced S-adenosylhomocysteine as a coproduct during the transfer.

A team led by . . .

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