Issue Date: February 20, 2017 | Web Date: February 16, 2017
New amination chemistry brought to light
Flashes of light help chemists at Princeton University and Bristol-Myers Squibb drive the hydroaminations of olefins to produce substituted amines. The light-powered reaction gives chemists another tool for installing amines in drugs and other biologically important molecules.
The new hydroamination is noteworthy for its intermolecular reactivity, its use of unactivated olefin substrates, its toleration of several different functional groups, and its regioselectivity for anti-Markovnikov amine products—wherein the new C–N bond forms on the less substituted . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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