Issue Date: February 20, 2017 | Web Date: February 15, 2017
Pinning a bull’s-eye on cancer cells
A new small-molecule strategy could help target cancer drugs selectively to tumors with the help of click chemistry (Nat. Chem. Biol. 2017, DOI: 10.1038/nchembio.2297).
Many cancer drugs attack healthy tissue in addition to tumors, leading to harmful side effects. So scientists want to target therapeutics to cancer cells more selectively.
One such approach that has reached the clinic is antibody-drug conjugates. Antibodies recognize antigens, such as HER2 . . .
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