Volume 95 Issue 9 | p. 5 | News of The Week
Issue Date: February 27, 2017 | Web Date: February 23, 2017

Surprising amyloid structure solved

Bacterial peptide forms amyloids with α-helices instead of β-sheets; new structures could be targets for antibiotics
Department: Science & Technology
News Channels: Biological SCENE, Analytical SCENE
Keywords: structural biology, amyloids

When Meytal Landau, a structural biologist at Technion—Israel Institute of Technology, recently solved the structure of some peptide fibrils she believed were amyloids, she nearly fell out of her chair. She expected to see the β-sheet architecture that’s common to all known amyloid fibrils. Instead, she saw the first known α-helical version (Science 2017, DOI: 10.1126/science.aaf4901).

Amyloid fibrils are protein aggregates . . .

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