Web Date: December 7, 2017
New target for anti-inflammatory drugs found
Immune cells in our bodies use toll-like receptors (TLRs) to recognize bits and pieces of invading pathogens. For example, one type of TLR, TLR8, sits in the membranes of cellular compartments called endosomes and looks for single-stranded RNA from viruses. When TLR8 binds to a piece of viral RNA, it activates an immune response to attack the invader.
Unfortunately, these receptors can get overactive and trigger inflammation when a pathogen isn’t present. As a result, . . .
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