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Web Date: December 7, 2017

New target for anti-inflammatory drugs found

Small molecule inhibits toll-like receptor through novel mechanism
Department: Science & Technology
Keywords: Drug discovery, toll-like receptors (TLRs), inhibitor, inflammation, inflammatory conditions

Immune cells in our bodies use toll-like receptors (TLRs) to recognize bits and pieces of invading pathogens. For example, one type of TLR, TLR8, sits in the membranes of cellular compartments called endosomes and looks for single-stranded RNA from viruses. When TLR8 binds to a piece of viral RNA, it activates an immune response to attack the invader.

Unfortunately, these receptors can get overactive and trigger inflammation when a pathogen isn’t present. As a result, . . .

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Chemical & Engineering News
ISSN 0009-2347
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