Latest News
Web Date: December 21, 2017

Scientists use directed evolution to develop better viruslike capsules

Artificial viral capsids that hold their own genomic material could aid drug delivery
Department: Science & Technology
Keywords: Synthetic biology, virus, capsid, directed evolution, drug delivery

Viruses are pretty simple: They’re small DNA or RNA genomes enclosed in protein containers called capsids. Scientists have designed and engineered proteins that self-assemble into viruslike containers that hold cargoes such as drugs, vaccines, and biomolecules.

David Baker of the University of Washington and coworkers have now devised the first so-called nucleocapsids, artificial capsids that enclose their own RNA genomes. The development opens the door for researchers to use directed evolution, a repetitive protein mutation . . .

To view the rest of this content, please log in with your ACS ID.



 
Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society