Issue Date: January 29, 2018 | Web Date: January 25, 2018
Structure of antipsychotic drug target solved
Two years ago at a scientific meeting, Bryan L. Roth of the University of North Carolina, Chapel Hill, announced that he and his colleagues were trying to solve the structure of the D2 dopamine receptor (DRD2), a target of many antipsychotic drugs. Researchers at the session told him not to waste his time, Roth says. Many groups previously had tried to obtain high-resolution structures of DRD2 bound to drugs but had failed because the complexes . . .
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