Volume 96 Issue 9 | p. 7 | News of The Week
Issue Date: February 26, 2018 | Web Date: February 22, 2018

Aryl C–H bonds succumb to fluorination

Transition-metal-fluoride electrophile reacts with druglike molecules
Department: Science & Technology
News Channels: Organic SCENE
Keywords: Fluorination, arenes, aryl C–H

A general and mild method for turning aromatic C–H bonds into C–F bonds offers chemists a way to create fluorinated molecules that were difficult to make before. Because the chemistry tolerates a broad range of functional groups, it can fluorinate molecules in the later stages of a chemical synthesis—to make novel pharmaceutical or agrochemical candidates, for example (Nature 2018, DOI: 10.1038/nature25749).

Chemists have already come up with good ways . . .

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