Advertisement

This site uses cookies to enhance your user experience. By continuing to use this site you are agreeing to our COOKIE POLICY.

ACCEPT AND CLOSE

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

The key to knowledge is in your (nitrile-gloved) hands

Already an ACS Member?  

Basic

$0 Community Associate

ACS’s Basic Package keeps you connected with C&EN and ACS.

  • Access to 6 digital C&EN articles per month on cen.acs.org
  • Weekly delivery of the C&EN Essential newsletter
JOIN NOW
Standard

$80 Regular Members & Society Affiliates

ACS’s Standard Package lets you stay up to date with C&EN, stay active in ACS, and save.

Eligibility restrictions apply. Review ACS Membership Packages to see if you qualify.

JOIN NOW
Premium

$160 Regular Members & Society Affiliates
$55 Graduate Students
$25 Undergraduate Students

ACS’s Premium Package gives you full access to C&EN and everything the ACS Community has to offer.

  • Unlimited access to C&EN’s daily news coverage on cen.acs.org
  • Weekly delivery of the C&EN Magazine in print or digital format
  • Access to our Chemistry News by C&EN mobile app
  • Significant discounts on registration for most ACS-sponsored meetings
ACS offers discounts for some countries outside the United States. This discount is shown at checkout, if applicable.

JOIN NOW

Thank you!

Your account has been created successfully, and a confirmation email is on the way.

Your username is now your ACS ID.

ENJOY UNLIMITED ACCES TO C&EN

Infectious disease

Periodic Graphics

Periodic Graphics: A short history of antiviral drugs

Chemical educator and Compound Interest blogger Andy Brunning lists some notable compounds that target viruses.

by Andy Brunning, special to C&EN
January 30, 2022 | A version of this story appeared in Volume 100, Issue 4
Advertisement

Most Popular in Biological Chemistry

 

To download a pdf of this article, visit http://cenm.ag/antiviralhistory.

References used to create this graphic:

Dance, Amber. “The Challenges of Antiviral Treatments.” Knowable Magazine, Feb. 9, 2021.

De Clercq, Erik. “Antivirals: Past, Present and Future.” Biochem. Pharmacol. (2013). DOI: 10.1016/j.bcp.2012.12.011.

De Clercq, Erik. “Antivirals and Antiviral Strategies.” Nat. Rev. Microbiol. (2004). DOI: 10.1038/nrmicro975.

De Clercq, Erik, and Guangdi Li. “Approved Antiviral Drugs over the Past 50 Years.” Clin. Microbiol. Rev. (2016). DOI: 10.1128/CMR.00102-15.

Dolgin, Elie. “The Race for Antiviral Drugs to Beat COVID—and the Next Pandemic.” Nature, April 14, 2021.

Field, Hugh J., and Erik De Clercq. “Antiviral Drugs–a Short History of Their Discovery and Development.” Microbiology Today, May 1 2004.

Kausar, Shamaila, Fahad Said Khan, Muhammad Ishaq Mujeeb Ur Rehman, Muhammad Akram, Muhammad Riaz, Ghulam Rasool, Abdul Hamid Khan, Iqra Saleem, Saba Shamim, Arif Malik. “A Review: Mechanism of Action of Antiviral Drugs.” Int. J. Immunopathol. Pharmacol. (2021). DOI: 10.1177/20587384211002621

 

A collaboration between C&EN and Andy Brunning, author of the popular graphics blog Compound Interest

To see more of Brunning’s work, go to compoundchem.com. To see all of C&EN’s Periodic Graphics, visit http://cenm.ag/periodicgraphics.

CORRECTION:

This graphic was updated on February 9, 2022, to correct the structure of saquinavir.
The graphic was updated on March 17, 2022, to correct the stereochemistry of the amide side chain of saquinavir. The central amide group should be connected by a wedge, not a dash.

 

Article:

This article has been sent to the following recipient:

0 /1 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.
GET MORE
GET MORE