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Start-ups

Precision BioSciences partners with University of Pennsylvania to develop gene editing therapies

by Ryan Cross
September 9, 2018 | A version of this story appeared in Volume 96, Issue 36
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Durham, N.C.-based start-up Precision BioSciences is expanding its collaboration with the University of Pennsylvania to develop therapies based on its Arcus gene editing technology, an alternative to CRISPR gene editing. The duo’s three-year partnership will use Arcus to inactivate genes in nonhuman primates. Penn’s famous gene therapy scientist, James Wilson, recently used Arcus to inactivate a gene called PCSK9 and lower cholesterol in macaques (Nat. Biotechnol. 2018, DOI: 10.1038/nbt.4182). The pair may also develop therapies to repair or introduce genes with Arcus.

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