Optimizing Analysis of Polycyclic Aromatic
Hydrocarbons (PAHs) using In Situ MS Source Conditioning
Tuesday, June 18, 2013
USA 11:00 a.m. EDT, 10:00 a.m. CDT, 8:00 a.m. PDT, 16:00 BST
Who should attend?
• Analysts using GC/MS and GC/MS/MS techniques to analyze PAHs in environmental samples, food and other matrices
• Management personnel interested in optimizing PAH analysis in their laboratory
• GC/MS and GC/MS/MS operators facing difficulty with PAH analysis
Senior Applications Chemist
Gas Phase Division Solutions Group,
Polycyclic aromatic hydrocarbons (PAHs) are included on US Environmental Protection Agency (EPA), US Food and Drug Administration (FDA), and National Oceanic and Atmospheric Administration (NOAA) pollutant lists because of their mutagenic and carcinogenic properties. Researchers monitoring PAH contamination in environmental samples have faced difficulty in achieving detection limits required by regulatory authorities due to poor peak shape, variation in peak response, and non-linear calibration curves.
Agilent Technologies, Inc. has introduced a programmable module for in situ source conditioning that addresses these analytical limitations. This presentation will introduce the new module, discuss its operating modes, and review how using a slow bleed of conditioning gas into the MS during analysis helps analysts optimize PAH analysis by single quad GC/MS and triple quad GC/MS/MS systems.
Subject Areas Covered In Presentation:
• PAH analysis presents analytical challenges regardless of matrix
• In Situ conditioning of the MS source overcomes reported problems with PAH analysis
• Applicable to single quad and triple quad MS systems, in situ conditioning of the MS source:
- Optimizes PAH analysis through a user programmed bleed of conditioning gas into the MS during analysis
- Improves chromatography
- Stabilizes response factors
- Improves linearity of calibration curves
- Reduces cleaning frequency of the MS source
• The presentation will include a review of improvements in data quality achieved in analysis of PAHs by GC/MS and GC/MS/MS