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How fab are your mAbs? A complete aggregate analysis workflow for comprehensive, efficient and reliable characterisation of monoclonal Antibodies

European Broadcast: October 24, 2017: 9:00am EDT, 2:00pm BST, 3:00 CET

US Broadcast: October 24, 2017: 11:00am EDT, 10:00am CDT, 8:00 CET

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Overview

 

Monoclonal antibodies (mAbs) are of huge pharmaceutical significance because they can be specifically designed to effectively target critical pathogenic molecules and therefore modulate the natural course of serious disease. Produced by cell culture, however, mAbs contain numerous variants and may also contain dimers and higher order aggregates. This is problematic and can be highly detrimental to the efficacy and safety as well as impacting production yield.

Although there is an intense focus on product quality and consistency throughout mAb production, both upstream during expression or downstream during purification, minimising aggregation remains a primary concern. This has ensured that novel analytical workflows that allow batch quality to be rapidly and reliably confirmed are of huge interest and economic value.

In this webinar we will present details of a complete aggregate analysis workflow that couples multiple analytical techniques to provide an efficient and reliable measure of mAb aggregation – all the way from a simple, non-destructive measurement that provides a qualitative indication if a sample is aggregated or not through to techniques that accurately quantify dimers and higher order aggregates, and which deliver greater insights into the protein.

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Key Learning Objectives:

 

• How to ensure that the mAbs in your workflow are always of the highest quality.

• How to take advantage of a complete workflow solution to improve your productivity, reduce your operating costs and maximize your profitability.

Who Should Attend:

 

• Researchers

• Researchers/ R&D Mangagers

• Laboratory Managers/ Directors / Supervisors

• Laboratory Technicians / Operators

 

Speakers

 
Dr. Kevin Grant, Ph. D.,
Molecular Spectroscopy Product Manager,
Agilent Technologies
Dr. Andrew Coffey, Ph.D.,
Applications Chemist,
Agilent Technologies
 

Moderator

 
Britt Erikson,
Senior Editor,
 

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