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_____ Brought to you by Evonik _____

Continuous Processes: Customized Solutions for the Manufacturing of Fine Chemicals and APIs



  First Session: October 23, 2018

  11:00am EDT, 5:00pm CEST, 11:00pm China

  Repeat Session: October 30, 2018

  9:00am CET, 4:00pm China, 4:00am EDT




Many complex and multi-stage API syntheses involve transformations for which batch processing has significant limitations in terms of safety, quality, yield and/or feasibility. Even at moderate manufacturing scales, which are typical for the pharmaceutical and fine chemical industries, the continuous processing benefits become more obvious for pharmaceutical companies, API manufacturers and regulatory authorities.

This webinar will examine the benefits and advantages of using continuous processing for the manufacturing of fine chemicals and APIs, illustrated by industrial case studies.

Presentation 1: "Flow Chemistry - Concepts and Tools" by Dr. Patrick Löb

Continuous processing is playing an increasing role in the development and manufacturing of Active Pharmaceutical Ingredients (APIs). This presentation specifically outlines concepts and tools of flow chemistry based on milli- and microstructure reactors. Benefit topics - improved process controls, the accessibility of novel process windows, straightforward scale-up, and operational advantages - are discussed and illustrated by selected application examples. Challenges such as the handling of solids are addressed.

Presentation 2: "Continuous Processing – A Powerful Tool for High Value Product Manufacturing at Evonik Health Care" by Dr. Michael Nonnenmacher

Evonik Health Care applies continuous processing technologies in the synthesis of APIs and fine chemicals particularly for manufacturing steps where additional value can be generated. The presentation outlines decision criteria for implementation of continuous steps and necessary tools and concepts for a successful process development. Selected examples highlighting the integration of several continuous unit operations for a multi-stage organometallic process are presented and strategies for bringing such processes to scale are revealed.

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Key Learning Objectives

  • How continuous processing is a powerful technology platform for fine chemical and API manufacturing
  • How continuous processing can result in faster, safer and more economical processes
  • Important differences and considerations between batch and continuous processes
  • Gain insight into effective CMO qualification, selection and project execution

Who Should Attend

  • Process development scientists
  • Process engineers
  • Researchers/R&D Managers
  • Laboratory Managers/Directors/Supervisors
  • Operations managers
  • Outsourcing managers
  • Safety and regulatory personnel
  • General/Senior management in the pharmaceutical industry


Dr. Patrick Löb,
Deputy Head of Division Energy and Chemical Technology,
Fraunhofer Institute for Microengineering and Microsystems Fraunhofer Institute for Microengineering and Microsystems, Mainz, Germany
Dr. Michael Nonnenmacher,
Group Head Innovation Management,
Evonik Nutrition & Care GmbH


Britt Erikson
Senior Editor,