CEN Webinars: Stronger Bonds
Pushing the limits of Light Scattering Detection for Biotherapeutic Characterization
Thursday April 24th 2014
USA 8:00 a.m. PDT / 11:00 a.m. EDT / 15:00 GMT
SPEAKERS
Speaker
Matthew McGann,
Technical/Scientific Advisor,
Malvern Instruments
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MODERATOR
Moderator
Britt E. Erickson, Ph.D.,
Senior Editor,
C&EN
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OVERVIEW

Albert Einstein once said, "Once we accept our limits, we go beyond them", and never a truer word has been spoken about the characterization of Biotherapeutic molecules. Candidate molecules are produced in such small quantities in early phases of development that it is often impossible to measure all properties of the sample that are required to make an informed decision. In this industry therefore, the single most limiting factor we must accept is the quantity of sample we have to work with.

With this in mind, this seminar will discuss the total characterization of a number of model biomolecules using Light Scattering Technologies developed at Malvern Instruments, including Dynamic Light Scattering, Electrophoretic Light Scattering and Multi-Angle Light Scattering combined with SEC. Data available from these techniques include size, charge, molecular weight, oligomeric or aggregation state, along with a range of intrinsic values relating to the state of stability within a formulation. A particular focus will be given to the limits of detection for these techniques, showing a range of information which can be obtained on as little as 50μL of sample.

KEY LEARNING OBJECTIVES

- Latest developments in biotherapeutic characterization for small volumes

- Biomolecule characterization using light scattering technologies including, Dynamic Light Scattering, Electrophoretic Light Scattering, and Multi-Angle Light Scattering

WHO SHOULD ATTEND
  • • Formulation Scientists - Bioformulation
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  • • Protein Scientists, Biochemists
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  • • QC and QA Development and Analytical Testing
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  • • Lab Managers and Facility Managers - Protein Research
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