Accurate API Assays by Non-Aqueous Titration
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Accurate API Assays by Non-Aqueous Titration

April 26, 2016

11:00am EDT, 8:00am PDT, 16:00 BST, 17:00 CEST

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Many assay methods described in the U.S. and European Pharmacopoeias rely on the accuracy and simplicity of titration. However, the majority of APIs, intermediates and starting materials are only weakly acidic or weakly basic, therefore, their solubility makes titration challenging. Analytical labs often resort to complex HPLC methods to analyze final products that come in many forms; such as ointments, tablets, and lotions. A titration using non-aqueous solvents is a more reliable and accurate alternative to these LC methods. In this webinar you will learn about the significant advantages of non-aqueous titration for assay determination. We will also explore solvent selection and its relationship with pKa/pKb values, electrode selection and titration parameter optimization.

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Key Learning Objectives:


• Understand the effect of solvents in pharmaceutical titrations

• Learn key principles of method development for non-aqueous titrations

• Electrode care and optimization tips for non-aqueous titrations

Who Should Attend:


• Lab Managers interested in a fast alternative assay determination method to HPLC

• R&D and analytical chemists from the pharmaceutical & nutraceutical industries

• Anyone interested in learning the benefits of non-aqueous titration for assay determination



Tom Hess,
Technical Support Specialist,
Metrohm USA
Sheldon Henry
Technical Applications Specialist,
Metrohm Canada


Celia Arnaud,
Senior Editor,

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