USA 11:00am EST, 8:00 am PST, 16:00 GMT
Inorganic Product Specialist,
National Institute on Minority Health & Health Disparities
Cisplatin, carboplatin, and oxaliplatin are some of the most widely used cancer chemotherapy drugs in the Western world. Treatment efficacy is related to cellular uptake of cisplatin, and thus intracellular platinum content. Many cancers are initially responsive to platinum treatment but often exhibit drug resistance that involves the efflux of anti-cancer drugs from cancer cells thereby severely limiting the therapeutic outcomes.
Traditional methods to assess cisplatin uptake in cells involves digesting a cell population and measuring the total platinum content. The downfall of this approach is that it does not reflect the distribution and individual cellular variation of cisplatin uptake, nor does it provide information on the cisplatin content by cell cycle.
- Introduction to Single Cell operating mode
- Application of Single Cell ICP-MS to differentiate between the varied uptake of cisplatin levels due to asynchronous cells in different phases of the cell cycle
- Application of Single Cell ICP-MS to look into nanoparticle uptake by individual cells
- Ability to quantitate the discreet number of nanoparticles in individual cells