CEN Webinars: Stronger Bonds
Quantification of Metal Content in Individual Cells using Single Cell Analysis by ICP-MS: An Insight into Cancer Treatment
Tuesday March 22nd 2016
USA 11:00am EST, 8:00 am PST, 16:00 GMT
SPEAKERS
Speaker
Chady Stephan, PhD,
Inorganic Product Specialist,
PerkinElmer
 
Speaker
Lauren Amable, PhD,
Staff Scientist,
National Institute on Minority Health & Health Disparities
Spacer
MODERATOR
Moderator
Jeff Huber,
Associate Editor,
C&EN
Register Now
OVERVIEW

Cisplatin, carboplatin, and oxaliplatin are some of the most widely used cancer chemotherapy drugs in the Western world. Treatment efficacy is related to cellular uptake of cisplatin, and thus intracellular platinum content. Many cancers are initially responsive to platinum treatment but often exhibit drug resistance that involves the efflux of anti-cancer drugs from cancer cells thereby severely limiting the therapeutic outcomes.

Traditional methods to assess cisplatin uptake in cells involves digesting a cell population and measuring the total platinum content. The downfall of this approach is that it does not reflect the distribution and individual cellular variation of cisplatin uptake, nor does it provide information on the cisplatin content by cell cycle.

KEY LEARNING OBJECTIVES:

- Introduction to Single Cell operating mode

- Application of Single Cell ICP-MS to differentiate between the varied uptake of cisplatin levels due to asynchronous cells in different phases of the cell cycle

- Application of Single Cell ICP-MS to look into nanoparticle uptake by individual cells

- Ability to quantitate the discreet number of nanoparticles in individual cells

WHO SHOULD ATTEND
  • • ICP-MS Instrument Researchers & Practitioners
  •  
  • • Nano Research: Government, Nanomedicine, Biomedical Nanotechnology, Cancer researchers, Pharmaceutical researchers
  •  
SPONSOR
Sponsor Logo